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Thrasher and Blastus are two teenage robots who live on the planet of Insanus. Their planet is inhabited by murderous robots who seek to kill one another for no apparent reason. Slightly less horrific than their peers, the duo seek to make it through high school, and navigate their lives with mixed results. Thrasher (Patton Oswalt), a tall and lanky robot, wishes to gain the affections of an attractive female robot named Maimy (Jessie Cantrell). Meanwhile, Blastus (John Gemberling), a small and rotund robot, just wants to be popular. As with Blastus, unlike most robots on Insanus, he is mostly sensitive and non-criminal, much to the disapproval of his mother. In his quest to be cool, however, he is incredibly impulsive and overconfident in his abilities. Thrasher, though calm and reserved, often falls prey to Blastus' badly-thought out plans.
Other characters include various schoolmates and staff members. Weenus (Michael Sinterniklaas) is a nerdy, psychopathic robot who is even lower on the social pyramid than the protagonists. Dreadnot (Dana Snyder) is a teacher at Harry S. Apocalypse High who finds joy in torturing and invoking pain into his students. Their principal, Thunderbite (also voiced by Snyder), is an over sized, skull-shaped robot who, when not causing pain, acts sweet and paternal toward the students. Megawatt (also voiced by Sinterniklaas) is a spoiled rich kid who is attractive to the female robots, most of whom he blows up; to Thrasher's disdain, he is dating Maimy. Tacklebot (Roger Craig Smith), Megawatt's friend and muscle head jock, acts violent and hostile toward the protagonists